Trichosetin, a novel tetramic acid antibiotic produced in dual culture of Trichoderma harzianum and Catharanthus roseus Callus.

@article{Marfori2002TrichosetinAN,
  title={Trichosetin, a novel tetramic acid antibiotic produced in dual culture of Trichoderma harzianum and Catharanthus roseus Callus.},
  author={Eufrocinio C. Marfori and Shin'ichiro Kajiyama and Eiichiro Fukusaki and Akio Kobayashi},
  journal={Zeitschrift fur Naturforschung. C, Journal of biosciences},
  year={2002},
  volume={57 5-6},
  pages={465-70}
}
The dual culture of Trichoderma harzianum and Catharanthus roseus callus produced an antimicrobial compound with a remarkable activity against the Gram-positive bacteria Staphylococcus aureus and Bacillus subtilis. Structural elucidation revealed that this compound, which we have named trichosetin, is a novel tetramic acid (2,4-pyrrolidinedione) antibiotic and a homolog of the fungal metabolite equisetin. This compound however, was not produced in the individual culture of T. harzianum or C… CONTINUE READING

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