Trichoplax, the simplest known animal, contains an estrogen-related receptor but no estrogen receptor: Implications for estrogen receptor evolution.

@article{Baker2008TrichoplaxTS,
  title={Trichoplax, the simplest known animal, contains an estrogen-related receptor but no estrogen receptor: Implications for estrogen receptor evolution.},
  author={Michael E. Baker},
  journal={Biochemical and biophysical research communications},
  year={2008},
  volume={375 4},
  pages={
          623-7
        }
}
  • M. Baker
  • Published 31 October 2008
  • Biology
  • Biochemical and biophysical research communications

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References

SHOWING 1-10 OF 50 REFERENCES

An amphioxus orthologue of the estrogen receptor that does not bind estradiol: Insights into estrogen receptor evolution

Comparison of extant ERs suggests that the ancestral ER did not bind estradiol and that it gained the ability to be regulated by estradio specifically in the vertebrate lineage, before lamprey split.

The Octopus vulgaris estrogen receptor is a constitutive transcriptional activator: evolutionary and functional implications.

It is shown that the Octopus ER is a strong constitutive transcriptional activator from canonical estrogen response elements, similar to those observed with the Aplysia ER and support the hypothesis that the evolving ER gained constitutive activity deep in the mollusk lineage.

Evolutionary genomics of nuclear receptors: from twenty-five ancestral genes to derived endocrine systems.

Notably, differential gene loss played an important role in the evolution of different nuclear receptor sets in bilaterian lineages and was also shaped by periods of gene duplication in vertebrates, as well as a lineage-specific duplication burst in nematodes.

Novel estrogen receptor-related Transcripts in Marisa cornuarietis; a freshwater snail with reported sensitivity to estrogenic chemicals.

Novel molluskan steroid receptor transcripts orthologous to vertebrate estrogen receptors (ERs) and estrogen receptor-related receptors (ERS) from the freshwater snail Marisa cornuarietis are isolated, designated mcER-like and mcERR respectively.

Evolution of adrenal and sex steroid action in vertebrates: a ligand-based mechanism for complexity.

  • M. Baker
  • Biology
    BioEssays : news and reviews in molecular, cellular and developmental biology
  • 2003
Sequencing of genomes from a cephalochordate, such as amphioxus, and from hagfish and lamprey will establish early events in the evolution of steroid hormone signaling, and also allow genetic studies to elucidate how vertebrate complexity depends on steroid hormones.

Steroid receptor phylogeny and vertebrate origins

  • M. Baker
  • Biology
    Molecular and Cellular Endocrinology
  • 1997

Adrenal and sex steroid receptor evolution: environmental implications.

  • M. Baker
  • Biology, Medicine
    Journal of molecular endocrinology
  • 2001
The phylogeny indicates that adrenal and sex steroid receptors arose in a jawless fish or a protochordate and that changes in the sequence of the hormone-binding domain have slowed considerably in land vertebrates.

Resurrecting the Ancestral Steroid Receptor: Ancient Origin of Estrogen Signaling

These findings indicate that SRs are extremely ancient and widespread, having diversified from a primordial gene before the origin of bilaterally symmetric animals, and that this ancient receptor had estrogen receptor–like functionality.

Oyster estrogen receptor: cDNA cloning and immunolocalization.