Trichomes + roots + ROS = artemisinin: regulating artemisinin biosynthesis in Artemisia annua L.

@article{Nguyen2011TrichomesR,
  title={Trichomes + roots + ROS = artemisinin: regulating artemisinin biosynthesis in Artemisia annua L.},
  author={Khanhvan T. Nguyen and Patrick R. Arsenault and Pamela J Weathers},
  journal={In Vitro Cellular & Developmental Biology - Plant},
  year={2011},
  volume={47},
  pages={329-338}
}
Artemisinin is a highly effective sesquiterpene lactone therapeutic produced in the plant, Artemisia annua. Despite its efficacy against malaria and many other infectious diseases and neoplasms, the drug is in short supply mainly because the plant produces low levels of the compound. This review updates the current understanding of artemisinin biosynthesis with a special focus on the emerging knowledge of how biosynthesis of the compound is regulated in planta. 
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