Trichloroethylene ototoxicity: evidence for a cochlear origin.

  title={Trichloroethylene ototoxicity: evidence for a cochlear origin.},
  author={Laurence D. Fechter and Ye Liu and David Herr and Kevin M. Crofton},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  volume={42 1},
Trichloroethylene (TCE) is known to produce an unusual pattern of hearing impairment in laboratory animals marked by a preferential loss of threshold sensitivity at midfrequencies. The purpose of this research was to determine whether the TCE-induced auditory deficit results from cochlear dysfunction. Adult Long Evans hooded rats were exposed via inhalation to either 0 (clean air) or 4000 ppm TCE (6 h/day for 5 days). Auditory thresholds for 1-40 kHz tones were determined 3 weeks after exposure… CONTINUE READING
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