Trichloroethylene induced vitamin B(12) and folate deficiency leads to increased formic acid excretion in the rat.

@article{Dow2000TrichloroethyleneIV,
  title={Trichloroethylene induced vitamin B(12) and folate deficiency leads to increased formic acid excretion in the rat.},
  author={Jacky Dow and Trevor Green},
  journal={Toxicology},
  year={2000},
  volume={146 2-3},
  pages={123-36}
}
Exposure of rats to trichloroethylene induces a sustained excretion of large amounts of formic acid in urine. Both of the major metabolites, trichloroethanol and trichloroacetic acid, were found to induce this response, but not the minor metabolite S-(1, 2-dichlorovinyl) cysteine. Other polychlorinated solvents, including carbon tetrachloride and chloroform, also increased urinary formate excretion. Addition of folic acid either to diet or drinking water modulated the response indicating that… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 18 extracted citations

Similar Papers

Loading similar papers…