Trichloroethylene-induced mouse lung tumors: studies of the mode of action and comparisons between species.

@article{Green1997TrichloroethyleneinducedML,
  title={Trichloroethylene-induced mouse lung tumors: studies of the mode of action and comparisons between species.},
  author={Trevor Green and Guy Mainwaring and John R. Foster},
  journal={Fundamental and applied toxicology : official journal of the Society of Toxicology},
  year={1997},
  volume={37 2},
  pages={125-30}
}
CD-1 mice exposed to 450 ppm trichloroethylene, 6 hr/day, 5 days/week, for 2 weeks showed a marked vacuolation of lung Clara cells after the first exposure of each week and a marked increase in cell division after the last exposure of each week. The damage seen in mouse lung Clara cells is caused by an accumulation of chloral resulting from high rates of metabolism of trichloroethylene but poor clearance of chloral to trichloroethanol and its glucuronide. The activity and distribution of the… CONTINUE READING

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