Trichloroethylene effects on gene expression during cardiac development.

  title={Trichloroethylene effects on gene expression during cardiac development.},
  author={J Michael Collier and Ornella Selmin and Paula D. Johnson and Raymond B Runyan},
  journal={Birth defects research. Part A, Clinical and molecular teratology},
  volume={67 7},
BACKGROUND Halogenated hydrocarbon exposure is associated with changes in gene expression in adult and embryonic tissue. Our study was undertaken to identify differentially expressed mRNA transcripts in embryonic hearts from Sprague-Dawley rats exposed to trichloroethylene (TCE) or potential bio-transformation products dichloroethylene (DCE) and trichloroacetic acid (TCAA). METHODS cDNA subtractive hybridization was used to selectively amplify expressed mRNA obtained from control or… CONTINUE READING
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