Trichlorfon induces spindle disturbances in V79 cells and aneuploidy in male mouse germ cells.

@article{Sun2000TrichlorfonIS,
  title={Trichlorfon induces spindle disturbances in V79 cells and aneuploidy in male mouse germ cells.},
  author={F Y Sun and Thomas Ernst Schmid and Ernst Schmid and Adolf Baumgartner and I D Adler},
  journal={Mutagenesis},
  year={2000},
  volume={15 1},
  pages={17-24}
}
In order to assess the effects of trichlorfon on cell division and on aneuploidy induction, we conducted an in vitro assay for spindle disturbances using V79 cells and an in vivo assay for aneuploidy induction in meiosis of male mice using multicolour fluorescence in situ hybridization (FISH) with epididymal sperm. In the in vitro assay, the chemical caused a concentration-dependent increase in the incidence of initial and full c-mitoses in the dose range 40-120 microg/ml trichlorfon. The… CONTINUE READING
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