Trichinella spiralis Excretory–Secretory Products Induce Tolerogenic Properties in Human Dendritic Cells via Toll-Like Receptors 2 and 4

@inproceedings{Ili2018TrichinellaSE,
  title={Trichinella spiralis Excretory–Secretory Products Induce Tolerogenic Properties in Human Dendritic Cells via Toll-Like Receptors 2 and 4},
  author={Nata{\vs}a Ili{\'c} and A Gruden-movsesijan and Jelena Cvetkovic and Sergej Tomi{\'c} and Dragana Bozidar Vucevic and Carmen Aranzamendi and Miodrag {\vC}oli{\'c} and Elena Pinelli and Ljiljana Sofronic-Milosavljevic},
  booktitle={Front. Immunol.},
  year={2018}
}
Trichinella spiralis, as well as its muscle larvae excretory-secretory products (ES L1), given either alone or via dendritic cells (DCs), induce a tolerogenic immune microenvironment in inbred rodents and successfully ameliorate experimental autoimmune encephalomyelitis. ES L1 directs the immunological balance away from T helper (Th)1, toward Th2 and regulatory responses by modulating DCs phenotype. The ultimate goal of our work is to find out if it is possible to translate knowledge obtained… CONTINUE READING