Tricarboxylic acid cycle intermediates in human muscle at rest and during prolonged cycling.

@article{Gibala1997TricarboxylicAC,
  title={Tricarboxylic acid cycle intermediates in human muscle at rest and during prolonged cycling.},
  author={Martin J Gibala and Mark A Tarnopolsky and Terry E. Graham},
  journal={The American journal of physiology},
  year={1997},
  volume={272 2 Pt 1},
  pages={E239-44}
}
Previous studies have used the muscle concentration of citrate + malate + fumarate to estimate tricarboxylic acid (TCA) cycle pool size in humans [e.g., Am. J. Physiol. 259 (Cell Physiol. 28): C834-C841, 1990]. Our purpose was to quantify changes in individual TCA cycle intermediates (TCAI) and total pool size by measuring the concentrations of the eight TCAI in human muscle. Eight males cycled to exhaustion (Exh) at approximately 70% of their maximal oxygen uptake, and biopsies were obtained… CONTINUE READING

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