Tributyrin induces differentiation, growth arrest and apoptosis in androgen-sensitive and androgen-resistant human prostate cancer cell lines.

@article{Maier2000TributyrinID,
  title={Tributyrin induces differentiation, growth arrest and apoptosis in androgen-sensitive and androgen-resistant human prostate cancer cell lines.},
  author={Steffen Maier and E. -P. Reich and Rub{\'e}n Garc{\'i}a Martin and Max Georg Bachem and V Altug and Richard E. Hautmann and J{\"u}rgen Erich Gschwend},
  journal={International journal of cancer},
  year={2000},
  volume={88 2},
  pages={245-51}
}
Progression to androgen independence remains the main problem that impacts on survival and quality of life in prostate cancer patients. We have investigated the potency of tributyrin, an orally available prodrug of butyrate, to induce growth arrest, differentiation and apoptosis in LNCaP, PC-3 and TSU-PR1 human prostate cancer cell lines. Cells were treated with 0.1 to 5 mM tributyrin or sodium butyrate. Growth inhibition, cell cycle arrest and apoptosis induction was assessed using standard… CONTINUE READING