Tributyltin synergizes with 20-hydroxyecdysone to produce endocrine toxicity.

  title={Tributyltin synergizes with 20-hydroxyecdysone to produce endocrine toxicity.},
  author={Ying Hong Wang and Gwijun Kwon and Hong Li and Gerald A. LeBlanc},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  volume={123 1},
One of the great challenges facing modern toxicology is in predicting the hazard associated with chemical mixtures. The development of effective means of predicting the toxicity of chemical mixtures requires an understanding of how chemicals interact to produce nonadditive outcomes (e.g., synergy). We hypothesized that tributyltin would elicit toxicity in daphnids (Daphnia magna) by exaggerating physiological responses to 20-hydroxyecdysone signaling via synergistic activation of the retinoid X… CONTINUE READING
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