Tributyltin chloride induces renal dysfunction by inflammation and oxidative stress in female rats.

  title={Tributyltin chloride induces renal dysfunction by inflammation and oxidative stress in female rats.},
  author={Jo{\~a}o Victor S Coutinho and Leandro C Freitas-Lima and Frederico F. C. T. Freitas and Fl{\'a}via Priscila Santos Freitas and Priscila Lang Podratz and Rafaella P Lopes Magnago and Marcella Leite Porto and Silvana dos Santos Meyrelles and Elisardo Corral Vasquez and Poliane A A Brand{\~a}o and Maria Tereza Weitzel Dias Carneiro and Francisca Diana Paiva-Melo and Leandro Miranda-Alves and Ian V. Silva and Agata Lages Gava and Jones B Graceli},
  journal={Toxicology letters},
Tributyltin chloride (TBT) is an organometallic pollutant that is used as a biocide in antifouling paints. TBT induces several toxic and endocrine-disrupting effects. However, studies evaluating the effects of TBT on renal function are rare. This study demonstrates that TBT exposure is responsible for improper renal function as well as the development of abnormal morphophysiology in mammalian kidneys. Female rats were treated with TBT, and their renal morphophysiology was assessed… CONTINUE READING
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