Tributyltin acetate-induced immunotoxicity is related to inhibition of T cell development in the mouse thymus

Abstract

We studied the mechanism by which tributylin acetate (TBT) inhibits the development of T cells in the mouse thymus. After 7 days of oral TBT administration in mice, thymic weights were significantly decreased, and the expression of Troma-1, a thymic cortical epithelial cell marker, was also decreased in TBT-treated mice. The expression of cytokines produced… (More)
DOI: 10.1007/s13273-015-0022-6

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