Tribbles: novel regulators of cell function; evolutionary aspects

  title={Tribbles: novel regulators of cell function; evolutionary aspects},
  author={Zolt{\'a}n Hegedűs and Agnes Czibula and Endre Kiss-Toth},
  journal={Cellular and Molecular Life Sciences CMLS},
Identification of rate-limiting steps or components of intracellular second messenger systems holds promise to effectively interfere with these pathways under pathological conditions. The emerging literature on a recently identified family of signalling regulator proteins, called tribbles gives interesting clues for how these proteins seem to link several ‘independent’ signal processing systems together. Via their unique way of action, tribbles co-ordinate the activation and suppression of the… CONTINUE READING