Triazolothienopyrimidine inhibitors of urea transporter UT-B reduce urine concentration.

Abstract

Urea transport (UT) proteins facilitate the concentration of urine by the kidney, suggesting that inhibition of these proteins could have therapeutic use as a diuretic strategy. We screened 100,000 compounds for UT-B inhibition using an optical assay based on the hypotonic lysis of acetamide-loaded mouse erythrocytes. We identified a class of… (More)
DOI: 10.1681/ASN.2011070751

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