Triathlon for energy functions: who is the winner for design of protein-protein interactions?

@article{Sharabi2011TriathlonFE,
  title={Triathlon for energy functions: who is the winner for design of protein-protein interactions?},
  author={Oz Sharabi and Ayelet Dekel and Julia M. Shifman},
  journal={Proteins},
  year={2011},
  volume={79 5},
  pages={1487-98}
}
Computational prediction of stabilizing mutations into monomeric proteins has become an almost ordinary task. Yet, computational stabilization of protein–protein complexes remains a challenge. Design of protein–protein interactions (PPIs) is impeded by the absence of an energy function that could reliably reproduce all favorable interactions between the binding partners. In this work, we present three energy functions: one function that was trained on monomeric proteins, while the other two… CONTINUE READING