Triamcinolone acetonide modulates permeability and intercellular adhesion molecule-1 (ICAM-1) expression of the ECV304 cell line: implications for macular degeneration.

@article{Penfold2000TriamcinoloneAM,
  title={Triamcinolone acetonide modulates permeability and intercellular adhesion molecule-1 (ICAM-1) expression of the ECV304 cell line: implications for macular degeneration.},
  author={Philip L. Penfold and Lijun Wen and Michele C. Madigan and Mark C. Gillies and Nicholas J. C. King and Jan Marie Provis},
  journal={Clinical and experimental immunology},
  year={2000},
  volume={121 3},
  pages={458-65}
}
Whilst animal studies and a pilot clinical trial suggest that intravitreal triamcinolone acetonide (TA) may be useful in the treatment of age-related macular degeneration (AMD), its mode of action remains to be fully elucidated. The present study has investigated the capacity of TA to modulate the expression of adhesion molecules and permeability using a human epithelial cell line (ECV304) as a model of the outer blood-retinal barrier (BRB). The influence of TA on the expression of ICAM-1 and… CONTINUE READING
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