Trials and tribulations of using beta-amyloid precursor protein immunohistochemistry to evaluate traumatic brain injury in adults.

@article{Graham2004TrialsAT,
  title={Trials and tribulations of using beta-amyloid precursor protein immunohistochemistry to evaluate traumatic brain injury in adults.},
  author={David I. Graham and Colin K. Smith and Rachel Reichard and Pascale D Leclercq and S M Gentleman},
  journal={Forensic science international},
  year={2004},
  volume={146 2-3},
  pages={89-96}
}
Axonal pathology is increasingly identified by beta-amyloid precursor protein (betaAPP) immunohistochemistry in the brains of patients who may or may not have a history of trauma. The presence of betaAPP-IR(+) has been variously interpreted as either that diffuse traumatic axonal injury (TAI) is indeed a universal finding in cases of fatal traumatic brain injury (TBI) or there are other causes of betaAPP-IR(+) axons which under certain circumstances may be sufficient to mimic TBI and therefore… CONTINUE READING

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