Trial-selective effects of U50,488H, a κ-opioid receptor agonist, on consummatory successive negative contrast

@article{Wood2008TrialselectiveEO,
  title={Trial-selective effects of U50,488H, a κ-opioid receptor agonist, on consummatory successive negative contrast},
  author={Michael D. Wood and Jacob N. Norris and Angelitha Daniel and Mauricio R. Papini},
  journal={Behavioural Brain Research},
  year={2008},
  volume={193},
  pages={28-36}
}
A series of experiments studied the effects of the kappa-opioid receptor agonist U50,488H on consummatory successive negative contrast (cSNC) in rats. In cSNC, previous experience with a 32% sucrose solution leads to greater rejection of 4% sucrose than exclusive experience with 4% sucrose. Experiments 1 and 2 revealed that U50,488H failed to influence cSNC when administered before the first downshifted trial, but either attenuated (1mg/kg) or enhanced (3 and 10mg/kg) cSNC when administered… CONTINUE READING
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