Trial of short-course antimicrobial therapy for intraabdominal infection.

  title={Trial of short-course antimicrobial therapy for intraabdominal infection.},
  author={Robert G. Sawyer and Jeffrey A. Claridge and Avery B Nathens and Ori D. Rotstein and Therese Marie Duane and Heather L. Evans and Charles H Cook and Patrick O'neill and John E. Mazuski and Reza Askari and Mark A Wilson and Lena M. Napolitano and Nicholas Namias and Preston Roy Miller and E. Patchen Dellinger and Christopher M. Watson and R. Coimbra and Daniel L. Dent and Stephen F. Lowry and Christine S. Cocanour and Michaela A West and Kaysie L. Banton and William G. Cheadle and Pamela A. Lipsett and Christopher A. Guidry and Kimberley A Popovsky},
  journal={The New England journal of medicine},
  volume={372 21},
BACKGROUND The successful treatment of intraabdominal infection requires a combination of anatomical source control and antibiotics. The appropriate duration of antimicrobial therapy remains unclear. METHODS We randomly assigned 518 patients with complicated intraabdominal infection and adequate source control to receive antibiotics until 2 days after the resolution of fever, leukocytosis, and ileus, with a maximum of 10 days of therapy (control group), or to receive a fixed course of… CONTINUE READING
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