Trial of early, goal-directed resuscitation for septic shock.

@article{Mouncey2015TrialOE,
  title={Trial of early, goal-directed resuscitation for septic shock.},
  author={P Mouncey and Tiffany Medlin Osborn and Geraldine S. Power and David A Harrison and Md Zia Sadique and Richard D Grieve and Rahi Jahan and Sheila Harvey and Derek Bell and Julian Bion and Timothy J Coats and Mervyn Singer and J. Duncan Young and Kathryn M. Rowan},
  journal={The New England journal of medicine},
  year={2015},
  volume={372 14},
  pages={
          1301-11
        }
}
BACKGROUND Early, goal-directed therapy (EGDT) is recommended in international guidelines for the resuscitation of patients presenting with early septic shock. However, adoption has been limited, and uncertainty about its effectiveness remains. METHODS We conducted a pragmatic randomized trial with an integrated cost-effectiveness analysis in 56 hospitals in England. Patients were randomly assigned to receive either EGDT (a 6-hour resuscitation protocol) or usual care. The primary clinical… CONTINUE READING
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