Trial of Psilocybin versus Escitalopram for Depression.

@article{CarhartHarris2021TrialOP,
  title={Trial of Psilocybin versus Escitalopram for Depression.},
  author={Robin Lester Carhart-Harris and Bruna Giribaldi and Rosalind Watts and Michelle Baker-Jones and Ashleigh Murphy-Beiner and Robert Murphy and Jonny Martell and Allan Blemings and David Erritzoe and David J. Nutt},
  journal={The New England journal of medicine},
  year={2021},
  volume={384 15},
  pages={
          1402-1411
        }
}
BACKGROUND Psilocybin may have antidepressant properties, but direct comparisons between psilocybin and established treatments for depression are lacking. METHODS In a phase 2, double-blind, randomized, controlled trial involving patients with long-standing, moderate-to-severe major depressive disorder, we compared psilocybin with escitalopram, a selective serotonin-reuptake inhibitor, over a 6-week period. Patients were assigned in a 1:1 ratio to receive two separate doses of 25 mg of… 

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