Trial of Pimavanserin in Dementia-Related Psychosis.

@article{Tariot2021TrialOP,
  title={Trial of Pimavanserin in Dementia-Related Psychosis.},
  author={Pierre N. Tariot and Jeffrey L. Cummings and Maria Soto-martin and Clive Ballard and Deniz Erten‐Lyons and David L. Sultzer and Davangere P. Devanand and Daniel Weintraub and Bradley W. McEvoy and James M. Youakim and Srdjan Stankovic and Erin Pennock Foff},
  journal={The New England journal of medicine},
  year={2021},
  volume={385 4},
  pages={
          309-319
        }
}
BACKGROUND Patients with dementia due to neurodegenerative disease can have dementia-related psychosis. The effects of the oral 5-HT2A inverse agonist and antagonist pimavanserin on psychosis related to various causes of dementia are not clear. METHODS We conducted a phase 3, double-blind, randomized, placebo-controlled discontinuation trial involving patients with psychosis related to Alzheimer's disease, Parkinson's disease dementia, dementia with Lewy bodies, frontotemporal dementia, or… 
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