Triadin Binding to the C-Terminal Luminal Loop of the Ryanodine Receptor is Important for Skeletal Muscle Excitation–Contraction Coupling

@article{Goonasekera2007TriadinBT,
  title={Triadin Binding to the C-Terminal Luminal Loop of the Ryanodine Receptor is Important for Skeletal Muscle Excitation–Contraction Coupling},
  author={Sanjeewa A. Goonasekera and Nicole A Beard and Linda A Groom and Takashi Kimura and Alla D. Lyfenko and Andrew Rosenfeld and Isabelle Marty and Angela F Dulhunty and Robert T. Dirksen},
  journal={The Journal of General Physiology},
  year={2007},
  volume={130},
  pages={365 - 378}
}
Ca(2+) release from intracellular stores is controlled by complex interactions between multiple proteins. Triadin is a transmembrane glycoprotein of the junctional sarcoplasmic reticulum of striated muscle that interacts with both calsequestrin and the type 1 ryanodine receptor (RyR1) to communicate changes in luminal Ca(2+) to the release machinery. However, the potential impact of the triadin association with RyR1 in skeletal muscle excitation-contraction coupling remains elusive. Here we… CONTINUE READING

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