Triadin/Junctin Double Null Mouse Reveals a Differential Role for Triadin and Junctin in Anchoring CASQ to the jSR and Regulating Ca2+ Homeostasis

@inproceedings{Boncompagni2012TriadinJunctinDN,
  title={Triadin/Junctin Double Null Mouse Reveals a Differential Role for Triadin and Junctin in Anchoring CASQ to the jSR and Regulating Ca2+ Homeostasis},
  author={Simona Boncompagni and Monique A Thomas and Jos{\'e} Rafael L{\'o}pez and Paul D. Allen and Qunying Yuan and Evangelia G Kranias and Clara Franzini-armstrong and Claudio F. Perez},
  booktitle={PloS one},
  year={2012}
}
Triadin (Tdn) and Junctin (Jct) are structurally related transmembrane proteins thought to be key mediators of structural and functional interactions between calsequestrin (CASQ) and ryanodine receptor (RyRs) at the junctional sarcoplasmic reticulum (jSR). However, the specific contribution of each protein to the jSR architecture and to excitation-contraction (e-c) coupling has not been fully established. Here, using mouse models lacking either Tdn (Tdn-null), Jct (Jct-null) or both (Tdn/Jct… CONTINUE READING