Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors

  title={Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors},
  author={T. Chuang and R. Ulevitch},
  journal={Nature Immunology},
  • T. Chuang, R. Ulevitch
  • Published 2004
  • Biology, Medicine
  • Nature Immunology
  • Activation of Toll-like receptors (TLRs) results in a proinflammatory response needed to combat infection. Thus, limiting TLR signaling is essential for preventing a protective response from causing injury to the host. Here we describe how a RING finger protein, Triad3A, acts as an E3 ubiquitin-protein ligase and enhances ubiquitination and proteolytic degradation of some TLRs. Triad3A overexpression promoted substantial degradation of TLR4 and TLR9 with a concomitant decrease in signaling, but… CONTINUE READING
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