Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors

@article{Chuang2004Triad3AAE,
  title={Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors},
  author={Tsung-Hsien Chuang and Richard J Ulevitch},
  journal={Nature Immunology},
  year={2004},
  volume={5},
  pages={495-502}
}
Activation of Toll-like receptors (TLRs) results in a proinflammatory response needed to combat infection. Thus, limiting TLR signaling is essential for preventing a protective response from causing injury to the host. Here we describe how a RING finger protein, Triad3A, acts as an E3 ubiquitin-protein ligase and enhances ubiquitination and proteolytic degradation of some TLRs. Triad3A overexpression promoted substantial degradation of TLR4 and TLR9 with a concomitant decrease in signaling, but… 

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