Triacsin C inhibits the formation of 1H NMR-visible mobile lipids and lipid bodies in HuT 78 apoptotic cells.

@article{Iorio2003TriacsinCI,
  title={Triacsin C inhibits the formation of 1H NMR-visible mobile lipids and lipid bodies in HuT 78 apoptotic cells.},
  author={Egidio Iorio and Massimo Di Vito and Francesca Spadaro and Carlo Ramoni and Emanuela Lococo and Roberto Carnevale and Luisa Lenti and Roberto Strom and Franca Podo},
  journal={Biochimica et biophysica acta},
  year={2003},
  volume={1634 1-2},
  pages={
          1-14
        }
}
Nuclear magnetic resonance-visible mobile lipids (ML) have been reported to accumulate during cell apoptosis in vitro and in vivo. The biogenesis, biochemical nature and structure of these lipids are still under debate. In this study, a human lymphoblastoid cell line, HuT 78, was induced to apoptosis by exposure to anti-Fas monoclonal antibodies (alpha-Fas mAb) followed by incubation for different time intervals (1-24 h, hypodiploid cell fraction, H, varying from 1% to over 60%) either in the… CONTINUE READING
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