Tri-substituted acylhydrazines as tertiary amide bioisosteres: HCV NS5B polymerase inhibitors.

@article{Canales2012TrisubstitutedAA,
  title={Tri-substituted acylhydrazines as tertiary amide bioisosteres: HCV NS5B polymerase inhibitors.},
  author={Eda Canales and Joseph S Carlson and Todd Appleby and Martijn Fenaux and Johnny Lee and Yang Tian and Neeraj Tirunagari and Melanie Wong and William J. Watkins},
  journal={Bioorganic & medicinal chemistry letters},
  year={2012},
  volume={22 13},
  pages={4288-92}
}
The use of a tri-substituted acylhydrazine as an isostere of a tertiary amide was explored in a series of HCV NS5B thumb site II inhibitors. Direct replacement generated an analog with similar conformational and physicochemical properties. The series was extended to produce compounds with potent binding affinities and encouraging levels of cellular potency.