Treponema pallidum promotes macrophage polarization and activates the NLRP3 inflammasome pathway to induce interleukin-1β production

@inproceedings{Lin2018TreponemaPP,
  title={Treponema pallidum promotes macrophage polarization and activates the NLRP3 inflammasome pathway to induce interleukin-1β production},
  author={Li-Rong Lin and Wei Liu and Xiao-Zhen Zhu and Yu-Yan Chen and Zheng-Xiang Gao and Kun Gao and Man-li Tong and Hui-lin Zhang and Yao Xiao and Wen-Dong Li and Shu-lian Li and Hui-ling Lin and Li-li Liu and Zan-Xi Fang and Jianjun Niu and Yong Lin and Tian-Ci Yang},
  booktitle={BMC Immunology},
  year={2018}
}
BackgroundThe involvement of inflammasome activation and macrophage polarization during the process of syphilis infection remains unknown. In this study, A series of experiments were performed using human macrophages to research the role of NLRP3 inflammasome regulation in interleukin (IL)-1β production and its influence on macrophage polarization triggered by T. pallidum.ResultsThe results showed that in M0 macrophages treated with T. pallidum, the M1-associated markers inducible nitric oxide… CONTINUE READING
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