Treponema pallidum invades intercellular junctions of endothelial cell monolayers.

@article{Thomas1988TreponemaPI,
  title={Treponema pallidum invades intercellular junctions of endothelial cell monolayers.},
  author={David D Thomas and Mohamad Navab and David A. Haake and Alan M. Fogelman and James N. Miller and Michael A. Lovett},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1988},
  volume={85 10},
  pages={3608-12}
}
The pathogenesis of syphilis reflects invasive properties of Treponema pallidum, but the actual mode of tissue invasion is unknown. We have found two in vitro parallels of treponemal invasiveness. We tested whether motile T. pallidum could invade host cells by determining the fate of radiolabeled motile organisms added to a HeLa cell monolayer; 26% of treponemes associated with the monolayer in a trypsin-resistant niche, presumably between the monolayer and the surface to which it adhered, but… CONTINUE READING
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