Trends of selected malformations in relation to folic acid recommendations and fortification: an international assessment.

@article{Botto2006TrendsOS,
  title={Trends of selected malformations in relation to folic acid recommendations and fortification: an international assessment.},
  author={Lorenzo D Botto and Alessandra Lisi and Carol Bower and Mark A. Canfield and Nirupa Dattani and Catherine de Vigan and Hermien E K De Walle and David J. Erickson and Jane Halliday and Lorentz M. Irgens and Robert Brian Lowry and Robert McDonnell and J{\'u}lia M{\'e}tneki and Simone Poetzsch and Annukka Ritvanen and Elisabeth Robert-Gnansia and Csaba Siffel and Claude Stoll and Pierpaolo Mastroiacovo},
  journal={Birth defects research. Part A, Clinical and molecular teratology},
  year={2006},
  volume={76 10},
  pages={693-705}
}
BACKGROUND Two crucial issues relative to the benefits and impact of folic acid in the prevention of birth defects are whether supplementation recommendations alone, without fortification, are effective in reducing the population-wide rates of neural tube defects (NTDs), and whether such policies can reduce the occurrence of other birth defects. Using data from 15 registries, we assessed rates and trends of 14 major defects, including NTDs, in areas with official recommendations or… CONTINUE READING