Trends in the evolution of the proopiomelanocortin gene.

  title={Trends in the evolution of the proopiomelanocortin gene.},
  author={Robert M. Dores and Stephanie G Lecaude},
  journal={General and comparative endocrinology},
  volume={142 1-2},
The POMC gene is perhaps the most extensively studied member of the opioid/orphanin gene family. In Phylum Chordata this gene has been characterized in representatives of every class within the Gnathostomata, as well as in one representative agnathan vertebrate, the marine lamprey. This review provides a systematic overview of trends in the evolution of the melanocortins (ACTH/alpha-MSH, beta-MSH, gamma-MSH, and delta-MSH) and beta-endorphin in gnathostomes, and advances the hypothesis that the… CONTINUE READING