Trends in the epidemiology of focal segmental glomerulosclerosis.

@article{Kitiyakara2003TrendsIT,
  title={Trends in the epidemiology of focal segmental glomerulosclerosis.},
  author={Chagriya Kitiyakara and Jeffrey B. Kopp and Paul Eggers},
  journal={Seminars in nephrology},
  year={2003},
  volume={23 2},
  pages={
          172-82
        }
}
There is marked variation in the frequency of focal segmental glomerulosclerosis (FSGS) around the world. Recent studies of renal biopsy specimen archives from several institutions in the United States suggest that the incidence of FSGS has increased over the past 20 years. Indeed, FSGS has become the leading cause of idiopathic nephrotic syndrome in adults and has become increasingly common in children as well. Further, the data indicate that black individuals are at increased risk for… 

Figures and Tables from this paper

Is focal segmental glomerulosclerosis increasing in patients with nephrotic syndrome?

The results suggest that a shift in the pathological pattern of nephrotic syndrome in children might be occurring, resulting in an increase in FSGS frequency, which has major clinical significance due to the poorer prognosis associated with FSGS.

Focal Segmental Glomerulosclerosis: State-of-the-Art and Clinical Perspective

The pathogenesis, clinical approach to distinguish between the different causes, and current recommendations in the management of focal segmental glomerulosclerosis are examined.

Risk profiles of progression in primary focal segmental glomerulosclerosis

The data of this study indicate that children diagnosed with FSGS who are younger than 10 years and have elevated baseline DBP are more likely to develop kidney failure.

A circulating permeability factor in focal segmental glomerulosclerosis: the hunt continues

It is suggested that a different form of suPAR, which cannot be measured by presently available enzyme-linked immunosorbent assay, might be the culprit; however, it remains to be determined whether this is the case.

Available and incoming therapies for idiopathic focal and segmental glomerulosclerosis in adults

An overview on the treatment of idiopathic FSGS in adults is provided, citing the latest published trials and the most reliable pathogenetic hypotheses of the disease.

Epidemiological profile, clinico-pathological correlation and treatment response in adult patients with primary focal segmental glomerulosclerosis.

The aim of this study was to study the epidemiological profile of primary focal segmental renal glomerulosclerosis in adults, and to evaluate the response to treatment, predictors of poor response and risk factors in the progression to chronic kidney disease in patients.

Recent Progress in the Pathophysiology and Treatment of FSGS Recurrence

  • P. CravediJ. KoppG. Remuzzi
  • Medicine, Biology
    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
  • 2013
Despite consistent experimental and clinical evidence that treatment of proteinuria slows renal function decline in proteinuric nephropathies, maximal use of antiproteinuric agents such as renin angiotensin system antagonists is not routine in the management of FSGS recurrence.

Pathogenesis and therapy of focal segmental glomerulosclerosis: an update

This review focuses on recent advances in the molecular pathogenesis of FSGS and currently available therapeutic agents as well as potential novel therapies.

FSGS: Diagnosis and Diagnostic Work-Up

The discovery of potential novel biomarkers to diagnose FSGS and monitor disease activity has renewed interest in this disease.

Focal and segmental glomerulosclerosis and plasma cell proliferative disorders.

It is shown that FSGS and plasma cell disorders are temporally and epidemiologically linked and therapy for the underlying plasma cell disorder can lead to resolution of FSGS.
...

References

SHOWING 1-10 OF 48 REFERENCES

Increasing incidence of focal-segmental glomerulosclerosis among adult nephropathies: a 20-year renal biopsy study.

  • M. HaasB. SpargoS. Coventry
  • Medicine
    American journal of kidney diseases : the official journal of the National Kidney Foundation
  • 1995

Focal segmental glomerulosclerosis in adult African Americans.

The short-term renal outcome in nephrotic adult African Americans with treated FSGS is comparable to that of the non-African Americans, but their long-term prognosis may be poorer.

Racial differences in the incidence and renal outcome of idiopathic focal segmental glomerulosclerosis in children

A national survey to determine if FSGS is more virulent in black and Hispanic children is warranted is warranted.

Changing patterns in the histopathology of idiopathic nephrotic syndrome in children.

The study showed that the incidence of focal segmental glomerulosclerosis in children with idiopathic nephrotic syndrome has increased recently, and in African American children.

Distinct patterns of glomerular disease in Lima, Peru.

The epidemiology of glomerular disease in Lima, Peru, is distinct from most areas of the world, but has similarities to certain regions in Africa, in that MPGN is common whereas IgA nephropathy appears to be rare.

High incidence of focal segmental glomerulosclerosis in nephrotic syndrome of childhood

The study indicates nearly no change in the annual incidence of pediatric primary nephrotic syndrome, but a higher incidence of focal segmental glomerulosclerosis with reciprocal decline in the incidence of MCD.

Idiopathic collapsing focal segmental glomerulosclerosis: a clinicopathologic study.

Both glomerulosclerosis and certain features of tubular damage were independent predictors of the level of renal function at time of biopsy, but not of the rate of progression of renal insufficiency.

Focal segmental glomerulosclerosis. A common entity in nephrotic black adults.

It is concluded that even in the absence of drug addiction, focal segmental glomerulosclerosis is a common cause of primary glomersular disease in black adults, in whom it may represent a nonspecific glomerular reaction to injury.

Changing etiologies of unexplained adult nephrotic syndrome: a comparison of renal biopsy findings from 1976-1979 and 1995-1997.

Focal and segmental glomerulosclerosis in nephrotic syndrome: a new profile of adult nephrotic syndrome in Zaire.

A new histologic profile of NS in Zaire is defined, characterized by the predominance of FSG, a seven-fold increase in this entity compared with previous findings from the same milieu.