Trends in solubility of polymorphs.

@article{Pudipeddi2005TrendsIS,
  title={Trends in solubility of polymorphs.},
  author={Madhu Pudipeddi and Abu T M Serajuddin},
  journal={Journal of pharmaceutical sciences},
  year={2005},
  volume={94 5},
  pages={929-39}
}
Polymorphism of drug substances has been the subject of intense investigation in the pharmaceutical field for over 40 years. Considering the multitude of reports on solubility or dissolution of polymorphs in the literature, an attempt is made in this study to answer the question: How big is the impact of polymorphism on solubility? A large number of literature reports on solubility or dissolution of polymorphs were reviewed and the data were analyzed for trends in solubility ratio of polymorphs… CONTINUE READING