Trends in gabapentin and baclofen exposures reported to U.S. poison centers

  title={Trends in gabapentin and baclofen exposures reported to U.S. poison centers},
  author={K. Reynolds and R. Kaufman and Amanda S. Korenoski and L. Fennimore and Joshua Shulman and Michael Lynch},
  journal={Clinical Toxicology},
  pages={763 - 772}
Abstract Context: Prescriptions for nonopioid pharmacological therapies such as gabapentin and baclofen have been increasing. While gabapentin and baclofen are less likely than opioids to result in fatal overdose, they are each associated with dependence, misuse and adverse effects. Objective: The objective of this study is to evaluate and describe trends in adult exposures to gabapentin and baclofen reported to U.S. Poison Centers. Methods: This was a retrospective review of data collected by… Expand
Characterization of gabapentin use in Kentucky after reclassification as a Schedule V controlled substance.
Gabapentin is widely prescribed in Kentucky, with higher rates of use observed in females, those older than 55 years and individuals living in the Appalachian region, and future studies are needed to assess the risks associated with gabapentin use. Expand
Current Evidence on Abuse and Misuse of Gabapentinoids
Some evidence supports the notion that patients with opioid use disorders may be at an increased risk of abusing gabapentinoids and that individuals with a history of psychiatric disorders or substance use disorder seem to be at high risk. Expand
Response to Comment on “Gabapentinoid Benefit and Risk Stratification: Mechanisms Over Myth”
A targeted narrative review of the benefits and risks of gabapentinoids in the context of general medical, specialty pain management, and addiction medicine practice to ameliorate current confusion regarding the class of drugs among clinicians, pharmacists, and public health workers alike. Expand
Classics in Chemical Neuroscience: Baclofen.
The >60 year legacy of baclofen is captured by walking through the history, pharmacology, synthesis, drug metabolism, routes of administration and societal impact of this Classic in chemical neuroscience. Expand
Oral baclofen toxicity in older patients with chronic kidney disease
1. Herr M, Ankri J, Diard C, Hiance-Delahaye A. Removal of drugs for Alzheimer's disease from the list of reimbursable drugs in France: analysis of change in drug use, disease management andExpand
Trends in exposure to over-reach: a comment on the methodology of Reynolds et al. 2019
To the editor,Reynolds et al. use descriptive methodology, examining trends in gabapentin and baclofen exposures reported to poison control and associated underlying causes, and suggest the use of descriptive methodology is warranted. Expand
Prevention of non-medical use of drugs is the most important task of the state anti-drug policy of the Russian Federation, the effectiveness of which can largely be due to the professional awarenessExpand
Coprescription of Opioids With Other Medications and Risk of Opioid Overdose
Baclofen, lorazepam, and gabapentin, among other non-opioid medications, were associated with opioid overdose and similar patterns were observed in non-cancer patients and individuals who used only oxycodone. Expand
Clinical News.
  • I. Clough
  • Medicine
  • British journal of hospital medicine
  • 2019


Characterization Of Gabapentin Overdose Using A Poison Center Case Series
In this cases series, gabapentin exposures caused no or minimal toxicity, and patients remained asymptomatic with reported effects of drowsiness and ataxia. Expand
Baclofen overdose: drug experimentation in a group of adolescents.
Baclofen overdose may result in coma, apnea, autonomic disturbances, cardiac conduction abnormalities, and seizures, and Persistent symptoms were noted in some patients, despite nondetectable bacl ofen levels. Expand
Gabapentin misuse, abuse and diversion: a systematic review.
Empirical and case report evidence suggests that the anti-epileptic and analgesic medication gabapentin is being misused internationally, with substance abuse populations at special risk for misuse/abuse. Expand
Misuse of the γ-aminobutyric acid analogues baclofen, gabapentin and pregabalin in the UK.
The aim of this study was to determine the prevalence, frequency and sources of misuse of the GABA analogues (baclofen, gabapentin and pregabalin) in the UK, and to benchmark against existing national data provided by the 2011/2012 Crime Survey for England and Wales. Expand
Gabapentin use in a managed medicaid population.
Almost all patients in this sample from the Medicaid managed population received gabapentin for off-label indications, and evidence from clinical trials does not support the use of gabAPentin for many of the conditions treated with gABapentin in this study. Expand
Gabapentin, opioids, and the risk of opioid-related death: A population-based nested case–control study
Among patients receiving prescription opioids, concomitant treatment with gabapentin was associated with a substantial increase in the risk of accidental opioid-related mortality, and doctors should consider carefully whether to adjust opioid dose accordingly. Expand
Gabapentin use, abuse, and the US opioid epidemic: the case for reclassification as a controlled substance and the need for pharmacovigilance
State-by-state efforts to enhance pharmacovigilance are reported and a re-evaluation of the schedule status of gabapentin at the federal level, and design and implementation of a national pharmacov Vigilance program are called for. Expand
Gabapentinoid Abuse in Order to Potentiate the Effect of Methadone: A Survey among Substance Misusers
Background/Aims: There is emerging evidence of gabapentin and pregabalin (gabapentinoid) abuse, particularly in the substance misuse population, and some suggestion of gabapentinoids being abusedExpand
Prevalence of gabapentin in drug overdose postmortem toxicology testing results.
Routine gabapentin postmortem testing and linking of death certificate, medical examiner, coroner, toxicology, and prescription history data will provide more reliable information on the extent of gabAPentin misuse, diversion, and implications for clinical care. Expand
Assessing alcohol versus baclofen withdrawal syndrome in patients treated with baclofen for alcohol use disorder.
Both AWS and BWS should be considered in the case of acute confusion or delirium occurring in patients treated with baclofen for AUD, and further research should investigate to what extent GABA-A and GABA-B induce shared or distinct neuroadaptation processes and withdrawal syndromes. Expand