Trends in Upstream and Downstream Process Development for Antibody Manufacturing.

  title={Trends in Upstream and Downstream Process Development for Antibody Manufacturing.},
  author={Petra Gronemeyer and Reinhard Ditz and Jochen Strube},
  volume={1 4},
A steady increase of product titers and the corresponding change in impurity composition represent a challenge for development and optimization of antibody production processes. Additionally, increasing demands on product quality result in higher complexity of processes and analytics, thereby increasing the costs for product work-up. Concentration and composition of impurities are critical for efficient process development. These impurities can show significant variations, which primarily… CONTINUE READING
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