Trends in Upstream and Downstream Process Development for Antibody Manufacturing.

@article{Gronemeyer2014TrendsIU,
  title={Trends in Upstream and Downstream Process Development for Antibody Manufacturing.},
  author={Petra Gronemeyer and Reinhard Ditz and Jochen Strube},
  journal={Bioengineering},
  year={2014},
  volume={1 4},
  pages={188-212}
}
A steady increase of product titers and the corresponding change in impurity composition represent a challenge for development and optimization of antibody production processes. Additionally, increasing demands on product quality result in higher complexity of processes and analytics, thereby increasing the costs for product work-up. Concentration and composition of impurities are critical for efficient process development. These impurities can show significant variations, which primarily… CONTINUE READING
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Single-use technologies in biopharmaceutical manufacturing: A 10-year review of trends and the future

  • E. S. Langer, R. A. Rader
  • Eng. Life Sci. 2014,
  • 2014
Highly Influential
7 Excerpts

Bioprocess Design and Production Technology for the Future

  • J. Strube, F. Grote, R. Ditz
  • In Biopharmaceutical Production Technology,
  • 2012
Highly Influential
6 Excerpts

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