Trending gabapentin exposures in Kentucky after legislation requiring use of the state prescription drug monitoring program for all opioid prescriptions#

  title={Trending gabapentin exposures in Kentucky after legislation requiring use of the state prescription drug monitoring program for all opioid prescriptions\#},
  author={Kiran A Faryar and Ashley N. Webb and Bikash K. Bhandari and Timothy G. Price and George M. Bosse},
  journal={Clinical Toxicology},
  pages={398 - 403}
Abstract Objective: Gabapentin is a gamma-aminobutyric acid (GABA) analog approved by the Food and Drug Administration (FDA) for partial seizures and post-herpetic neuralgia. Due to its wide therapeutic window and minimal adverse effects, it is frequently prescribed for additional off-label uses. The purpose of this study was to characterize the number, exposure reason, medical outcomes, and disposition of gabapentin exposures reported to one regional poison control center (PCC). Methods: A… Expand
6 Citations
Day-of-Surgery Gabapentinoids and Prolonged Opioid Use: A Retrospective Cohort Study of Medicare Patients Using Electronic Health Records
In a large integrated health system, there was no evidence that preoperative gabapentinoids were associated with reduced risk of prolonged opioid use in patients undergoing a broad range of surgeries. Expand
Prescription History Before Opioid Overdose Death: PDMP Data and Responsible Prescribing.
Review of PDMP data in deceased patients can prevent unnecessary opioid prescribing and optimize clinical practice, and legislators could enact a policy such as Void All Prescriptions or VAP alerts to cancel all prescriptions for individuals who have died, reducing drug diversion. Expand
Extracorporeal Treatment for Gabapentin and Pregabalin Poisoning: Systematic Review and Recommendations From the EXTRIP Workgroup.
The EXTRIP workgroup suggests against performing ECTR in addition to standard care rather than standard care alone (weak recommendation, very low quality of evidence) for gabapentinoid poisoning in patients with normal kidney function. Expand
Comparing Changes in Controlled Substance Prescribing Trends by Provider Type.
Differences in prescription trends for Schedule II opioids and stimulants were noted for physicians, APRNs, and dentists following introduction of mandatory use of KASPER markedly differed based on provider type. Expand
Advances in prescription drug monitoring program research: a literature synthesis (June 2018 to December 2019).
There is a critical gap in existing PDMP literature assessing how these programs have impacted psychiatrists, their prescribing behaviors, and their patients, according to a review of studies published from June 2018 to December 2019. Expand
Gabapentin overdose
  • Reactions Weekly
  • 2019


Characterization Of Gabapentin Overdose Using A Poison Center Case Series
In this cases series, gabapentin exposures caused no or minimal toxicity, and patients remained asymptomatic with reported effects of drowsiness and ataxia. Expand
Misuse and Abuse of Pregabalin and Gabapentin: Cause for Concern?
Physicians considering prescribing gabapentinoids for neurological/psychiatric disorders should carefully evaluate a possible previous history of drug abuse, whilst being able to promptly identify signs of pregabalin/gabAPentin misuse and provide possible assistance in tapering off the medication. Expand
Suicide by Gabapentin Overdose
The circumstances and autopsy findings of a 62‐year‐old woman with a history of depression, whose death was caused by intentional ingestion of excess gabapentin, appear to be the first published report of a death due solely to gabAPentin toxicity. Expand
Gabapentin overdose in a military beneficiary.
Given the large volume ingestion with minimal morbidity, it appears that gabapentin has a wide therapeutic margin and may be safe in overdose. Expand
A Decade of Gabapentinoid Misuse: An Analysis of the European Medicines Agency’s ‘Suspected Adverse Drug Reactions’ Database
Analysis of proportional reporting ratios for drug abuse/dependence/intentional product misuse values seem to indicate that these adverse drug reactions were more frequently reported for pregabalin compared with gabapentin, especially in patients with a history of substance misuse. Expand
Meta-analyses of dose-exposure relationships for gabapentin following oral administration of gabapentin and gabapentin enacarbil
  • C. Chen
  • Medicine
  • European Journal of Clinical Pharmacology
  • 2013
The meta-analyses addressed issues associated with between-study variability; and confirmed the highly non-linear nature of dose-exposure relationships for gabapentin and the essentially linear relationships for GABapentin enacarbil. Expand
Gabapentin toxicity in renal failure: the importance of dose adjustment.
All doctors need to be aware of the need to review the indications for gabapentin use during periods of acute illness, especially with regard to renal impairment, and off-label use should be discouraged. Expand
Benefits and safety of gabapentinoids in chronic low back pain: A systematic review and meta-analysis of randomized controlled trials
Existing evidence on the use of gabapentinoids in CLBP is limited and demonstrates significant risk of adverse effects without any demonstrated benefit, given the lack of efficacy, risks, and costs associated. Expand
New uses for older drugs: the tales of aspirin, thalidomide, and gabapentin.
These descriptions of novel uses for established drugs represent a growing trend in medicine: gabapentin ( developed as an antiseizure medication) currently being used to treat chronic pain conditions and the aforementioned conditions; thalidomide (developed as a sedative and once removed from the market because of its propensity to produce birth defects) and its congeners currently being use to treat neoplastic diseases; and aspirin. Expand
The Worldwide Opioid Epidemic
The use of opioids has increased dramatically in the 21st century and the effect of drugs of abuse, including opioids, on the developing fetus and newborn has not received as much attention as the adult population. Expand