Tremulane sesquiterpenes from cultures of the fungus Phellinus igniarius and their vascular-relaxing activities

  title={Tremulane sesquiterpenes from cultures of the fungus Phellinus igniarius and their vascular-relaxing activities},
  author={Ronghua Yin and Zhen-Zhu Zhao and Heping Chen and Xia Yin and Xuan Ji and Zejun Dong and Zheng-Hui Li and Tao Feng and Jikai Liu},
  journal={Phytochemistry Letters},
Cytotoxic tremulanes and 5,6-secotremulanes, four new sesquiterpenoids from a plant-associated fungus X1-2
Abstract Two new tremulanes and two new 5,6-secotremulanes, davotremulanes A-D 1–4, along with four known compounds 5–8, were isolated from the culture extract of X1-2, an unidentified
Trichothecene and tremulane sesquiterpenes from a hallucinogenic mushroom Gymnopilus junonius and their cytotoxicity.
Findings provide experimental evidence suggesting the potential anti-cancer effects of trichothecene sesquiterpenes from a poisonous mushroom.
Irlactane and Tremulane Sesquiterpenes from the Cultures of the Medicinal Fungus Irpex lacteus HFG1102
A new irlactane-type, namely irlactin K (1), and 22 tremulane-type sesquiterpenes including fourteen previously undescribed ones, namely irpexolactins A–N (2–15), and a known irlactane-type
Two new sesquiterpenes from cultures of the fungus Irpex lacteus
Two new tremulane-type sesquiterpenes were isolated from cultures of the fungus Irpex lacteus and their structures were elucidated by spectroscopic data analysis.
Chemical Constituents and Their Bioactivities of Mushroom Phellinus rhabarbarinus.
The results of this assessment suggested that the lanostane triterpenoids in fruiting bodies of P. rhabarbarinus played key roles in its folk usages.
Conosiligins A-D, Ring-Rearranged Tremulane Sesquiterpenoids from Conocybe siliginea.
Conosiligins A-D (1-4), four ring-rearranged sesquiterpenoids, were isolated from cultures of the basidiomycete Conocybe siliginea. Their structures and absolute configurations were determined by
Pharmacological potential of wood inhabiting fungi of genus Phellinus Quél.: An overview
The present review accentuates the pharmacological potential of Phellinus b that is attributed to an array of bioactive constituents reported from different species this genus.


Homo- and heptanor-sterols and tremulane sesquiterpenes from cultures of Phellinus igniarius.
In preliminary in vitro assays, compounds 8, 9, 13, and 3beta-hydroxy-11,12-O-isopropyldrimene showed significant vascular-relaxing activities against phenylephrine-induced vasoconstriction with relaxing rates of 35.7%, 45.4%, 46.6%, and 32.1%, respectively, as compared with the blank control.
The tremulanes, a new group of sesquiterpenes from the aspen rotting fungus Phellinus tremulae
A series of new sesquiterpenes, the tremulanes, possessing a previously unreported substituted perhydroazulene carbon skeleton, has been isolated from liquid cultures of the aspen (Populus
Phelligridins C-F: cytotoxic pyrano[4,3-c][2]benzopyran-1,6-dione and furo[3,2-c]pyran-4-one derivatives from the fungus Phellinus igniarius.
Three unique pyrano[4,3-c][2]benzopyran-1,6-dione derivatives and a new furo[3,2-c]pyran-4-one, named phelligridins C-F (2-5), together with hispolon (8), (E)-4-(3,4-dihydroxyphenyl)but-3-en-2-one
Structures, biogenesis, and biological activities of pyrano[4,3-c]isochromen-4-one derivatives from the Fungus Phellinus igniarius.
Further chemical investigation of the Chinese medicinal fungus Phellinus igniarius has resulted in the isolation and structural elucidation of three pyrano[4,3-c]isochromen-4-one derivatives,
Vascular myorelaxing activity of isolates from South African Hyacinthaceae partly mediated by activation of soluble guanylyl cyclase in rat aortic ring preparations
To the authors' knowledge, this has been the first account describing the vasodilating activity of homoisoflavonoids and compound 3 proved an effective vasorelaxing agent, partly acting via the activation of soluble guanylyl cyclase.
Phelligridimer A, a highly oxygenated and unsaturated 26-membered macrocyclic metabolite with antioxidant activity from the fungus Phellinus igniarius.
Phelligridimer A showed antioxidant activity but was inactive to several human cancer cell lines and enzymes PTP1B and thrombin, and a possible biogenesis of 1 mediated by the fungal metabolite hispidin was postulated.
A unique highly oxygenated pyrano[4,3-c][2]benzopyran-1,6-dione derivative with antioxidant and cytotoxic activities from the fungus Phellinus igniarius.
Phelligridin G (1) showed antioxidant activity inhibiting rat liver microsomal lipid peroxidation and moderate selective cytotoxic activities against human cancer cell lines.
Absolute Stereostructures of Carabrane-Type Sesquiterpenes, Curcumenone, 4S-Dihydrocurcumenone, and Curcarabranols A and B: Vasorelaxant Activity of Zedoary Sesquiterpenes.
New carabrane-type sesquiterpenes, curcarabranols A and B, were isolated from zedoary together with the two known carabrane-type sesquiterpenes curcumenone and 4S-dihydrocurcumenone. The absolute