Tremor arrest with thalamic microinjections of muscimol in patients with essential tremor.

@article{Pahapill1999TremorAW,
  title={Tremor arrest with thalamic microinjections of muscimol in patients with essential tremor.},
  author={Peter A. Pahapill and Ronald Levy and Jonathan O. Dostrovsky and Karen D. Davis and Ali R. Rezai and R. R. Tasker and Andres M. Lozano},
  journal={Annals of neurology},
  year={1999},
  volume={46 2},
  pages={249-52}
}
Six patients undergoing stereotactic procedures for essential tremor received microinjections of muscimol (a gamma-aminobutyric acid-A [GABA(A)] agonist) into the ventralis intermedius thalamus in areas where tremor-synchronous cells were identified electrophysiologically with microelectrode recordings and where tremor reduction occurred with electrical microstimulation. Injections of muscimol but not saline consistently reduced tremor in each patient. The effect had a mean latency of 7 minutes… CONTINUE READING