Trehalose loading through the mitochondrial permeability transition pore enhances desiccation tolerance in rat liver mitochondria.

@article{Liu2005TrehaloseLT,
  title={Trehalose loading through the mitochondrial permeability transition pore enhances desiccation tolerance in rat liver mitochondria.},
  author={X Liu and Alptekin Aksan and Michael A Menze and S. C. Hand and Mehmet Toner},
  journal={Biochimica et biophysica acta},
  year={2005},
  volume={1717 1},
  pages={21-6}
}
Trehalose has extensively been used to improve the desiccation tolerance of mammalian cells. To test whether trehalose improves desiccation tolerance of mammalian mitochondria, we introduced trehalose into the matrix of isolated rat liver mitochondria by reversibly permeabilizing the inner membrane using the mitochondrial permeability transition pore (MPTP). Measurement of the trehalose concentration inside mitochondria using high performance liquid chromatography showed that the sugar… CONTINUE READING