Trehalose intake induces chaperone molecules along with autophagy in a mouse model of Lewy body disease.

@article{Tanji2015TrehaloseII,
  title={Trehalose intake induces chaperone molecules along with autophagy in a mouse model of Lewy body disease.},
  author={Kunikazu Tanji and Yasuo Miki and Atsushi Maruyama and Junsei Mimura and Tomoh Matsumiya and Fumiaki Mori and Tadaatsu Imaizumi and Ken Itoh and Koichi Wakabayashi},
  journal={Biochemical and biophysical research communications},
  year={2015},
  volume={465 4},
  pages={746-52}
}
The accumulation of mis-folded and/or abnormally modified proteins is a major characteristic of many neurodegenerative diseases. In Lewy body disease (LBD), which includes Parkinson's disease and dementia with Lewy bodies, insoluble α-synuclein is widely deposited in the presynaptic terminals as well as in the neuronal cytoplasm in distinct brain regions. It is well known that the autophagy-lysosome system serves as an efficient degradation pathway for abnormal molecules within cells. To test… CONTINUE READING
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