Trehalose-induced destabilization of interdigitated gel phase in dihexadecylphosphatidylcholine.

  title={Trehalose-induced destabilization of interdigitated gel phase in dihexadecylphosphatidylcholine.},
  author={H. Takahashi and H. Ohmae and I. Hatta},
  journal={Biophysical journal},
  volume={73 6},
Trehalose is believed to have the ability to protect some organisms against low temperatures. To clarify the cryoprotective mechanism of trehalose, the structure and the phase behavior of fully hydrated dihexadecylphosphatidylcholine (DHPC) membranes in the presence of various concentrations of trehalose were studied by means of differential scanning calorimetry (DSC), static x-ray diffraction, and simultaneous x-ray diffraction and DSC measurements. The temperature of the interdigitated gel… Expand
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