Trehalose and sucrose protect both membranes and proteins in intact bacteria during drying.

@article{Leslie1995TrehaloseAS,
  title={Trehalose and sucrose protect both membranes and proteins in intact bacteria during drying.},
  author={S B Leslie and Ella Israeli and Bruce Lighthart and John H. Crowe and Lois M. Crowe},
  journal={Applied and environmental microbiology},
  year={1995},
  volume={61 10},
  pages={3592-7}
}
The microorganisms Escherichia coli DH5 alpha and Bacillus thuringiensis HD-1 show an increased tolerance to freeze-drying when dried in the presence of the disaccharides trehalose and sucrose. When the bacteria were dried with 100 mM trehalose, 70% of the E. coli and 57% of the B. thuringiensis organisms survived, compared with 56 and 44%, respectively, when they were dried with sucrose. Only 8% of the E. coli and 14% of the B. thuringiensis organisms survived drying without the sugars… CONTINUE READING
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