Trehalose-6P synthase is essential for trehalase activation triggered by glucose, nitrogen source or heat shock, but not by osmostress, in Schizosaccharomyces pombe.

@article{Cansado1998Trehalose6PSI,
  title={Trehalose-6P synthase is essential for trehalase activation triggered by glucose, nitrogen source or heat shock, but not by osmostress, in Schizosaccharomyces pombe.},
  author={Jos{\'e} Cansado and Jer{\'o}nima Vicente-Soler and Teresa Soto and Joseph S Fernandez and Mariano Gacto},
  journal={Biochimica et biophysica acta},
  year={1998},
  volume={1381 3},
  pages={271-8}
}
Cells of Schizosaccharomyces pombe disrupted in the tps1+ gene, which encodes trehalose-6P synthase, were unable to increase trehalase activity in response to the addition of glucose or nitrogen source. Moreover, in contrast to normal cells, Deltatps1 cells did not increase trehalase activity by heat shock. Overexpression of tps1+ in cells devoid of trehalose-6P synthase restored the ability to increase trehalase after addition of nutrients or by heat shock. In glucose-repressed cells, which… CONTINUE READING

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