Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein.

Abstract

Trehalose, a disaccharide present in many non-mammalian species, protects cells against various environmental stresses. Whereas some of the protective effects may be explained by its chemical chaperone properties, its actions are largely unknown. Here we report a novel function of trehalose as an mTOR-independent autophagy activator. Trehalose-induced… (More)

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Cite this paper

@article{Sarkar2007TrehaloseAN, title={Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein.}, author={Sovan Sarkar and Janet E. Davies and Zebo Huang and Alan Tunnacliffe and David C Rubinsztein}, journal={The Journal of biological chemistry}, year={2007}, volume={282 8}, pages={5641-52} }