Trefoil family factor 2 is expressed in murine gastric and immune cells and controls both gastrointestinal inflammation and systemic immune responses.

@article{KurtJones2007TrefoilFF,
  title={Trefoil family factor 2 is expressed in murine gastric and immune cells and controls both gastrointestinal inflammation and systemic immune responses.},
  author={Evelyn A Kurt-Jones and Lucheng Cao and Frantisek Sandor and Arlin B. Rogers and Mark T. Whary and Prashant R Nambiar and Anna Cerny and Glennice Bowen and Jing Yan and Shigeo Takaishi and Alfred L Chi and George W. Reed and Jeanmarie Houghton and James G Fox and Timothy C Wang},
  journal={Infection and immunity},
  year={2007},
  volume={75 1},
  pages={471-80}
}
Trefoil family factor 2 (TFF2), also known as spasmolytic peptide, is a low-molecular-weight protein that is upregulated in gastric tissues infected with Helicobacter or having other inflammatory conditions, but a precise function is yet to be elucidated. The role of TFF2 in the development of gastritis, colitis, and inflammatory cytokine responses was examined both in vivo and in vitro using wild-type and TFF2 knockout mice. TFF2 knockout and wild-type mice were infected with Helicobacter… CONTINUE READING