Trefoil Factor 3 (TFF3) Is Regulated by Food Intake, Improves Glucose Tolerance and Induces Mucinous Metaplasia

@inproceedings{Ge2015TrefoilF3,
  title={Trefoil Factor 3 (TFF3) Is Regulated by Food Intake, Improves Glucose Tolerance and Induces Mucinous Metaplasia},
  author={Hongfei Ge and Jonitha Gardner and Xiaosu Wu and Ingrid C. Rulifson and Jinghong Wang and Yumei Xiong and Jingjing Ye and Edward Belouski and Ping Cao and Jie Tang and Ki Jeong Lee and Suzanne Coberly and Xinle Wu and Jamila S. Gupte and Lynn Miao and Li Yang and Natalie L Nguyen and Bei Shan and W E Yeh and Murielle M V{\'e}niant and Yang Li and H{\'e}l{\`e}ne Baribault and G. William Wong},
  booktitle={PloS one},
  year={2015}
}
Trefoil factor 3 (TFF3), also called intestinal trefoil factor or Itf, is a 59 amino acid peptide found as a homodimer predominantly along the gastrointestinal tract and in serum. TFF3 expression is elevated during gastrointestinal adenoma progression and has been shown to promote mucosal wound healing. Here we show that in contrast to other trefoil factor family members, TFF1 and TFF2, TFF3 is highly expressed in mouse duodenum, jejunum and ileum and that its expression is regulated by food… CONTINUE READING