Tree-type algorithm for statistical analysis in chronic toxicity studies.

  title={Tree-type algorithm for statistical analysis in chronic toxicity studies.},
  author={Chieko Hamada and Kazuyoshi Yoshino and Kiyoshi Matsumoto and Mamoru Nomura and Isao Yoshimura},
  journal={The Journal of toxicological sciences},
  volume={23 3},
An appropriate statistical methodology in toxicity studies has been discussed over the last two decades and many statistical methods have already been proposed. Many practical problems, however, still remain unresolved and most pharmaceutical industries have been using a tree-type algorithm routinely to analyze repeated-dose toxicity study data. In considering routine use of statistical analysis in toxicological studies, standardization of statistical methodology is necessary and the decision… CONTINUE READING

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