Tree-structured gatekeeping tests in clinical trials with hierarchically ordered multiple objectives.

  title={Tree-structured gatekeeping tests in clinical trials with hierarchically ordered multiple objectives.},
  author={Alex Dmitrienko and Brian L. Wiens and Ajit C. Tamhane and Xin Wang},
  journal={Statistics in medicine},
  volume={26 12},
This paper discusses a new class of multiple testing procedures, tree-structured gatekeeping procedures, with clinical trial applications. These procedures arise in clinical trials with hierarchically ordered multiple objectives, for example, in the context of multiple dose-control tests with logical restrictions or analysis of multiple endpoints. The proposed approach is based on the principle of closed testing and generalizes the serial and parallel gatekeeping approaches developed by… CONTINUE READING

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